TRIM dsDNA sensor to restrict innate immune response
نویسندگان
چکیده
منابع مشابه
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.
Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes. Recent studies have indicated that double-stranded DNA (dsDNA) induces potent innate immune responses via the induction of type I IFN (IFN) and IFN-inducible genes. However, the regulatory mechanisms underlying dsDNA-triggered signaling are not fully underst...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2013
ISSN: 1672-7681,2042-0226
DOI: 10.1038/cmi.2013.6